The moderator of the Peutz-Jeghers support group elist has been tireless in researching and reading journal articles related to PJS. The titles below are linked to abstracts. Some sites may require free registration to read abstracts. The full text articles may or may not be available online. If so, a subscription fee may be required to view them.
Updates will be done as often as possible to provide you with the latest research being done on the syndrome. Articles are listed in ascending order by date, newest being at the top and oldest at the bottom. If you experience any difficulties in finding the abstracts, please email the webmaster using the email link at the bottom of this page. Be sure to include the name of the abstract you are attempting to access.
Case Studies
PJS Pigmentation
Management, Surgeries, & Tests
COX2 (cyclooxygnease-2)
Cancer
Breast & Reproductive System Cancers
Colorectal Cancer
Pancreatic Cancer
Genetics
Peutz-Jeghers colonic tumour in a newborn [European journal of pediatric surgery. 2002 Apr;12(2):138-40]
Gastroduodenal intussusception due to Peutz-Jeghers syndrome in infancy [Pediatric surgery international. 2002 Mar;18(2-3):178-80]
Malignant ovarian sex cord tumor with annular tubules in a patient with Peutz-Jeghers syndrome: a case report [Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc. 2000 Apr;13(4):466-70]
Patient with Peutz-Jeghers syndrome and liver metastases from an unknown primary tumor [Nederlands tijdschrift voor geneeskunde. 2000 Apr 1;144(14):667-70] article in Dutch
Clinical characteristics of Peutz-Jeghers syndrome in Korean polyposis patients[International journal of colorectal disease. 2000 Feb;15(1):35-8]
Peutz-Jeghers syndrome: 78-year follow-up of the original family [Lancet. 1999 Apr 10;353(9160):1211-5]
Gastroduodenal intussusception due to Peutz-Jeghers syndrome. A case report[Hepato-gastroenterology. 1994 Apr;41(2):134-6]
Peutz-Jeghers syndrome: a clinicopathologic survey of the "Harrisburg family" with a 49-year follow-up [Gastroenterology. 1988 Dec;95(6):1535-40]
Peutz-Jeghers syndrome in children: report of two cases and review of the literature [Journal of pediatric surgery. 1983 Feb;18(1):1-6]
Peutz-Jeghers syndrome. A clinicopathologic study of a large family with a 27-year follow-up [Cancer. 1982 Nov 15;50(10):2139-46]
A family with Peutz-Jeghers syndrome and bilateral breast cancer [Cancer. 1980 Aug 15;46(4):815-7]
Peutz Jeghers syndrome. 6 patients in a family [Revista de gastroenterologia de Mexico. 1977 Jan-Apr;42(1):23-35] article in Spanish
Treatment of facial lentigines in peutz-jeghers syndrome with an intense pulsed light source [Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]. 2002 Nov;28(11):1079-81]
Association of Peutz-Jeghers-like mucocutaneous pigmentation with breast and gynecologic carcinomas in women [Medicine; analytical reviews of general medicine, neurology, psychiatry, dermatology, and pediatries. 2000 Sep;79(5):293-8]
Management, Surgeries, & Tests
Long-term results of polyp clearance by intraoperative enteroscopy in the Peutz-Jeghers syndrome [Diseases of the colon and rectum. 2003 Jan;46(1):48-50]
Preimplantation genetic diagnosis in clinical practice [Journal of Medical Genetics 2002;39:6-11]
Heritable colorectal cancer syndromes: recognition and preventive management[Gastroenterology clinics of North America. 2002 Dec;31(4):1107-31]
Peutz-Jeghers syndrome [The American journal of gastroenterology. 2000 Mar;95(3):596-604]
Peutz-Jeghers syndrome: a new understanding [Journal of Korean medical science. 1999 Feb;14(1):2-7]
Peutz-Jeghers syndrome: risks of a hereditary condition [Scandinavian journal of gastroenterology. Supplement. 1999;230:64-70]
Towards decreasing the relaparotomy rate in the Peutz-Jeghers syndrome: the role of peroperative small bowel endoscopy [The British journal of surgery. 1990 Mar;77(3):301-2]
Peutz-Jeghers syndrome: its natural course and management [The Johns Hopkins medical journal. 1975 Feb;136(2):71-82]
Cyclooxygenase 2 expression and molecular alterations in Peutz-Jeghers hamartomas and carcinomas [Clinical cancer research : an official journal of the American Association for Cancer Research. 2003 Aug 1;9(8):3065-72]
Overexpression of cyclooxygenase 2 in hamartomatous polyps of Peutz-Jeghers syndrome [The American journal of gastroenterology. 2003 Mar;98(3):671-8]
Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis [Proceedings of the National Academy of Sciences of the United States of America. 2002 Sep 17;99(19):12327-32. Epub 2002 Sep 06]
Support groups for cancer patients [Support Care Cancer. 2003 Dec;11(12):763-8. Epub 2003 Oct 15.]
Support groups for cancer patients [Support Care Cancer. 2003 Dec;11(12):763-8. Epub 2003 Oct 15.]
Cancer patients' preferences for written prognostic information provided outside the clinical context [British Journal of Cancer. 2003 Oct 20;89(8):1450-6.]
The case for early detection [Nature Reviews Cancer 3, 243 -252 (2003); doi:10.1038/nrc1041] (April 2003 Vol 3 No 4) --Free registration required to view abstract. Contact the webmaster for assistance.
Issues and Progress with Protein Kinase Inhibitors for Cancer Treatment [Nature Reviews Drug Discovery 2, 296-313 (2003)] Full Article -- Also available in .pdf format
Preimplantation genetic diagnosis for cancer predisposition [Reproductive biomedicine online. 2002 Sep-Oct;5(2):148-55]
Very high risk of cancer in familial Peutz-Jeghers syndrome [Gastroenterology 2000 Dec;119(6):1447-53]
Pathogenesis of adenocarcinoma in Peutz-Jeghers syndrome [Cancer research. 1998 Dec 1;58(23):5267-70]
Increased risk for cancer in patients with the Peutz-Jeghers syndrome [Annals of internal medicine. 1998 Jun 1;128(11):896-9]
Breast & Reproductive System Cancers
Risk of breast and ovarian cancer in women with strong family histories [Oncology (Huntington). 2001 Jul;15(7):889-902; discussion 902, 905-7, 911-13]
Peutz-Jeghers syndrome. Association of duodenal and bilateral breast cancers in the same patient [Digestive diseases and sciences. 1984 Feb;29(2):178-82]
Dietary fibre and colorectal adenoma in a colorectal cancer early detection programme [Lancet. 2003 May 3;361(9368):1491-5]
Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study [Lancet. 2003 May 3;361(9368):1496-501]
Hereditary polyposis syndromes and hereditary non-polyposis colorectal cancer [Best practice & research. Clinical gastroenterology. 2003 Apr;17(2):237-58]
Joint effects of family history and adult life dietary risk factors on colorectal cancer risk [Epidemiology (Cambridge, Mass.) 2002 May;13(3):360-3]
Independent and joint effects of family history and lifestyle on colorectal cancer risk: implications for prevention [Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 1999 Jan;8(1):45-51]
Pancreatic cancer biology and genetics [Nature Reviews Cancer 2, 897-909 (2002); doi:10.1038/nrc949]
The tumor suppressor gene LKB1 is associated with prognosis in human breast carcinoma [Clinical cancer research : an official journal of the American Association for Cancer Research. 2002 Jul;8(7):2085-90]
Prevention of pancreatic cancer and strategies for management of familial pancreatic cancer [Digestive diseases. 2001;19(1):76-84]
Familial pancreatic cancer [Cancer journal. 2001 Jul-Aug;7(4):266-73]
Correlation of staining for LKB1 and COX-2 in hamartomatous polyps and carcinomas from patients with Peutz-Jeghers syndrome [The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 2003 Dec; 51(12): 1665-72]
Stability of the Peutz-Jeghers syndrome kinase LKB1 requires its binding to the molecular chaperones Hsp90/Cdc37 [Oncogene. 2003 Dec 11; 22(57): 9165-75.]
Mutations in the STK11 gene characterize minimal deviation adenocarcinoma of the uterine cervix [Laboratory investigation; a journal of technical methods and pathology. 2003 Jan;83(1):35-45]
A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity [Nature 421, 379 - 384 (2003); doi:10.1038/nature01296]
Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation [Nature 419, 162 - 167 (2002); doi:10.1038/nature01045]
Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis [Proceedings of the National Academy of Sciences of the United States of America. 2002 Sep 17;99(19):12327-32. Epub 2002 Sep 06]
LKB1--a master tumour suppressor of the small intestine and beyond [Nature reviews. Cancer. 2002 Jul;2(7):529-35]
Two novel mutations and a new STK11/LKB1 gene isoform in Peutz-Jeghers patients [Human mutation. 2002 Jul;20(1):78-9]
Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice [Cancer research. 2002 Apr 15;62(8):2261-6]
Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome [The Biochemical journal. 2002 Mar 1;362(Pt 2):481-90]
STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas [American journal of pathology. 2001 Dec;159(6):2017-22]
Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice [Science. 2001 Aug 17; 293: 1323-1326]
The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death [Molecular cell. 2001 Jun;7(6):1307-19]
CDX2 mutations do not account for juvenile polyposis or Peutz-Jeghers syndrome and occur infrequently in sporadic colorectal cancers [British journal of cancer. 2001 May 18;84(10):1314-6]
Molecular genetic alterations in hamartomatous polyps and carcinomas of patients with Peutz-Jeghers syndrome [Journal of clinical pathology. 2001 Feb;54(2):126-31]
Somatic mutations of LKB1 and beta-catenin genes in gastrointestinal polyps from patients with Peutz-Jeghers syndrome [Cancer research. 2000 Nov 15;60(22):6311-3]
LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo [The Biochemical journal. 2000 Feb 1;345 Pt 3:673-80]
Somatic mutations in the STK11/LKB1 gene are uncommon in rare gynecological tumor types associated with Peutz-Jegher's syndrome [American journal of pathology. 2000 Jan;156(1):339-45]
Genetic heterogeneity in Peutz-Jeghers syndrome [Human mutation. 2000;16(1):23-30]
STK11/LKB1 germline mutations are not identified in most Peutz-Jeghers syndrome patients [Clinical genetics. 1999 Aug;56(2):136-41]
Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers [American journal of pathology. 1999 Jun;154(6):1835-40]
Allele loss and mutation screen at the Peutz-Jeghers (LKB1) locus (19p13.3) in sporadic ovarian tumours [British journal of cancer. 1999 Apr;80(1-2):70-2]
Somatic mutations in the Peutz-Jeghers (LKB1/STKII) gene in sporadic malignant melanomas [The Journal of investigative dermatology. 1999 Apr;112(4):509-11]
A distinct region of chromosome 19p13.3 associated with the sporadic form of adenoma malignum of the uterine cervix [Cancer research. 1998 Mar 15;58(6):1140-3]
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Update: 27.Jan.'04