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The LKB1/Lung Cancer Connection: Footnotes
A Report by Stephanie Sugars

1Giardiello FM, Brensinger JD, Tersmette AC, Goodman SN, Petersen GM, Booker SV, Cruz-Correa M, Offerhaus JA. Very high risk of cancer in familial Peutz-Jeghers syndrome. Gastroenterology. 2000 Dec;119(6):1447-53.
PMID: 11113065 [PubMed - indexed for MEDLINE]

2M, Parrella P, Esteller M, Nomoto S, Trink B, Engles JM, Westra WH, Herman JG, Sidransky D. Inactivation of LKB1/STK11 Is a Common Event in Adenocarcinomas of the Lung. Cancer Res. 2002 Jul 1;62(13):3659-3662.
PMID: 12097271 [PubMed - as supplied by publisher]

3Giardiello FM, Welsh SB, Hamilton SR, Offerhaus GJ, Gittelsohn AM, Booker SV, Krush AJ, Yardley JH, Luk GD. Increased risk of cancer in the Peutz-Jeghers syndrome. N Engl J Med. 1987 Jun 11;316(24):1511-4.
PMID: 3587280 [PubMed - indexed for MEDLINE]

4Spigelman AD, Murday V, Phillips RK. Cancer and the Peutz-Jeghers syndrome. Gut. 1989 Nov;30(11):1588-90.
PMID: 2599445 [PubMed - indexed for MEDLINE]

5Boardman LA, Thibodeau SN, Schaid DJ, Lindor NM, McDonnell SK, Burgart LJ, Ahlquist DA, Podratz KC, Pittelkow M, Hartmann LC. Increased risk for cancer in patients with the Peutz-Jeghers syndrome. Ann Intern Med. 1998 Jun 1;128(11):896-9.
PMID: 9634427 [PubMed - indexed for MEDLINE]

6Burdick D, Prior JT. Peutz-Jeghers syndrome. A clinicopathologic study of a large family with a 27-year follow-up. Cancer. 1982 Nov 15;50(10):2139-46.
PMID: 7127254 [PubMed - indexed for MEDLINE]

7Utsunomiya J, Gocho H, Miyanaga T, Hamaguchi E, Kashimure A. Peutz-Jeghers syndrome: its natural course and management. Johns Hopkins Med J. 1975 Feb;136(2):71-82.
PMID: 1117595 [PubMed - indexed for MEDLINE]

8Dormandy, Thomas. Gastrointestinal polyposis with mucocutaneous pigmentation (Peutz-Jeghers syndrome). NEJM 1957 Jun 6 256(24):1093-1102.

9Boardman LA, Couch FJ, Burgart LJ, Schwartz D, Berry R, McDonnell SK, Schaid DJ, Hartmann LC, Schroeder JJ, Stratakis CA, Thibodeau SN. Genetic heterogeneity in Peutz-Jeghers syndrome. Hum Mutat. 2000;16(1):23-30.
PMID: 10874301 [PubMed - indexed for MEDLINE]

10Dozios RR, Judd ES, Dahlin DC, et al. The Peutz-Jeghers syndrome: Is there a predisposition to the development of intestinal malignancy? Arch Surg. 1969; 98:509-516

11Hirano S, Takiguchi Y, Igari H, Hiroshima K, Shingyoji M, Watanabe R, Moriya T, Tanabe N, Tatsumi K, Kuriyama T. A case of pulmonary adenocarcinoma accompanied by superior vena caval thrombosis in a patient with Peutz-Jeghers syndrome. Jpn J Clin Oncol 2002 Aug;32(8):307-9
PMID: 12411569

12Jimenez AI, Fernandez P, Dominguez O, Dopazo A, Sanchez-Cespedes M. Growth and molecular profile of lung cancer cells expressing ectopic LKB1: down-regulation of the phosphatidylinositol 3'-phosphate kinase/PTEN pathway. Cancer Res 2003 Mar 15;63(6):1382-8
PMID: 12649203

13Karuman P, Gozani O, Odze RD, Zhou XC, Zhu H, Shaw R, Brien TP, Bozzuto CD, Ooi D, Cantley LC, Yuan J. The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death. Mol Cell. 2001 Jun;7(6):1307-19.
PMID: 11430832

14Luukko K, Ylikorkala A, Tiainen M, Makela TP. Expression of LKB1 and PTEN tumor suppressor genes during mouse embryonic development. Mech Dev. 1999 May;83(1-2):187-90.
PMID: 10381580

15Bardeesy N, Sinha M, Hezel AF, Signoretti S, Hathaway NA, Sharpless NE, Loda M, Carrasco DR, DePinho RA. Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature. 2002 Sep 12;419(6903):162-7.
PMID: 12226664

16[No authors listed] Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 24-1975. N Engl J Med. 1975 Jun 19;292(25):1340-5.
No abstract available. PMID: 1128608

 

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Update: 20.May'04