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Drugs & PJS: Footnotes
A Report by Stephanie Sugars

1Yoo LI, Chung DC, Yuan J. LKB1--a master tumour suppressor of the small intestine and beyond. Nat Rev Cancer. 2002 Jul;2(7):529-35. Review. No abstract available.
PMID: 12094239 [PubMed - indexed for MEDLINE]

2Collins SP, Reoma JL, Gamm DM, Uhler MD. LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo. Biochem J. 2000 Feb 1;345 Pt 3:673-80.
PMID: 10642527 [PubMed - indexed for MEDLINE]

3Boudeau J, Kieloch A, Alessi DR, Stella A, Guanti G, Resta N. Functional analysis of LKB1/STK11 mutants and two aberrant isoforms found in Peutz-Jeghers Syndrome patients. Hum Mutat. 2003 Feb;21(2):172.
PMID: 12552571 [PubMed - indexed for MEDLINE]

4McGarrity TJ, Peiffer LP, Amos CI, Frazier ML, Ward MG, Howett MK. Overexpression of cyclooxygenase 2 in hamartomatous polyps of Peutz-Jeghers syndrome. Am J Gastroenterol 2003 Mar;98(3):671-8
PMID: 12650805

5Rossi DJ, Ylikorkala A, Korsisaari N, Salovaara R, Luukko K, Launonen V, Henkemeyer M, Ristimaki A, Aaltonen LA, Makela TP. Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis. Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12327-32.
PMID: 12218179 [PubMed - indexed for MEDLINE]
Full text Available for free at http://www.ncbi.nlm.nih.gov/PubMed/

6Suphat Subongkot, Pharm.D., David Frame, Pharm.D., William Leslie, M.D., Deborah Drajer, Pharm.D. Selective Cyclooxygenase-2 Inhibition: A Target in Cancer Prevention and Treatment Pharmacotherapy
http://www.medscape.com/viewarticle/448279

 

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Update: 19.May'04